Class:                                                                                                     
Glucocorticosteroid

Action:
Methylprednisolone is a synthetic steroid that suppresses acute and chronic inflammation and may alter the immune response. In addition, it potentiates vascular smooth muscle relaxation by beta-adrenergic agonists and may alter airway hyperactivity

Indications:
Suspected Addisonian crisis (cardiovascular collapse in patient at risk for adrenal insufficiency)
Anaphylaxis / Allergic Reaction
COPD

Precautions/Contraindications:
Evidence of active GI bleed

Adult Dosing:

• 125 mg, IV/IO bolus, slowly, over 2 minutes

Pediatric Dosing:

• • 2 mg/kg, IV/IO bolus, slowly, over 2 minutes to max dose of 125 mg

Notes/Special Considerations: 

• Must be reconstituted and used immediately
• The effect of methylprednisolone is generally delayed for several hours.
• Methylprednisolone is not considered a first line drug. Be sure to attend to the patient’s primary treatment priorities (i.e. airway, ventilation, beta-agonist nebulization) first. If primary treatment priorities have been completed and there is time while in route to the hospital, then methylprednisolone can be administered. Do not delay transport to administer this drug